Young Rachel Kalama, growing up in idyllic Honolulu in the 1890s, dreams of seeing far-off lands, but at the age of seven Rachel's dreams are shattered by the discovery that she has leprosy. Forcibly removed from the family, she's sent to an isolated leprosy settlement on the island of Moloka'i. In exile Rachel finds a family of friends to replace the family she's lot - but loss remains a constant shadow as Rachel watches those she loves succumb to the ravages of leprosy. Moloka'i is a story of hope, dignity, and the strength of the human spirit.